Research into the connection between heart failure and kidney failure


The combination of heart and kidney failure is also called ‘cardiorenal syndrome’

AMICARE opened in Aachen on 20 October. In this research institute, researchers from Maastricht UMC+ and RWTH Aachen University work together to uncover the relationship between cardiovascular problems and kidney disease. It is one of the first European institutes where researchers from different countries from different disciplines will collaborate so intensively on this medically urgent problem.

The combination of heart and kidney failure is also called ‘cardiorenal syndrome’. This is a common problem: more than 40% of patients with heart failure also have kidney failure. Yet little is known about it. It is clear that people with chronic kidney disease have an increased risk of heart failure. Conversely, people with reduced pump function (heart failure) also have problems with their kidneys more often than average. However, it is often not clear what is cause and effect.

AMICARE
Researchers and professors Erik Biessen, Leon Schurgers and Tilman Hackeng from the Cardiovascular Research Institute Maastricht (CARIM) in Maastricht UMC+ research cardiovascular diseases, where they have worked closely with RWTH Aachen for more than 15 years. Based on the successful collaboration within two major European research projects coordinated by each of these institutes, they drew up plans for further collaboration with the Aachen Initiatives and Professors Joachim Jankowski, Jürgen Floege, Nikolaus Marx and Dr. Heidi Noel’s. This led to the establishment of a bilateral and binational research institute AMICARE with a laboratory on the campus in Aachen. AMICARE stands for “Aachen-Maastricht Institute for Cardiorenal Disease”.

The best of both worlds
Leon Schurgers from MUMC+, professor of biochemistry of vascular calcification, is delighted: ‘With AMICARE we combine the best of both worlds. In Maastricht, for example, we have extensive knowledge of the molecular side of cardiovascular diseases. RWTH Aachen has great expertise in kidney research and has a number of unique cohorts and biobanks with data from people with chronic kidney disease. The technology available at each university is also complementary. If you combine the expertise and technology of both centres, you can do more and more targeted research.’

Transgressive
The collaboration crosses borders in two ways, explains Professor of Experimental Vascular Pathology at Maastricht UMC+ Erik Biessen: ‘Of course we break down national borders. Fortunately, this happens more and more often in science. But the best researchers from different fields also work together in AMICARE: the cardiovascular system and the kidneys. These are research fields that still often operate separately. This collaboration allows us to view our patients in a more holistic way and study their complex disease in its entirety.’

Translational research
The research institute focuses on translational research, which aims to translate fundamental research results into applications for the patient. This means, on the one hand, that researchers will continue to investigate the mechanisms and causes of the convergence of heart, vascular and kidney problems. But on the other hand, the researchers also expect to be able to speed up research into the early recognition and treatment of this syndrome with AMICARE, for example with medicine.


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Name author and/or edited by:
Maastricht UMC+
Photographer or photo agency: :
INGI images
Source of this article::
Maastricht UMC+
What is the URL for this resource?:
https://www.mumc.nl/actueel/nieuws/amicare-grensoverkruisend-onderzoek-naar-Relatie-hartfalen-en-nierfalen
Original title:
AMICARE: Cross-border research into the relationship between heart failure and kidney failure
Audience:
Healthcare staff, students
Date:
2022-10-30

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